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Topology in Molecular Biology

Biological and Medical Physics, Biomedical Engineering

Erschienen am 12.02.2010, Auflage: 1/2007
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Bibliografische Daten
ISBN/EAN: 9783642062421
Sprache: Englisch
Umfang: xiv, 238 S., 112 s/w Illustr., 6 farbige Illustr.,
Einband: kartoniertes Buch

Beschreibung

The book presents a class of new results in molecular biology for which topological methods and ideas are important. These include: the large-scale conformation properties of DNA; computational methods (Monte Carlo) allowing the simulation of large-scale properties of DNA; the tangle model of DNA recombination and other applications of Knot theory; dynamics of supercoiled DNA and biocatalitic properties of DNA; the structure of proteins; and other very recent problems in molecular biology. The text also provides a short course of modern topology intended for the broad audience of biologists and physicists. The authors are renowned specialists in their fields and some of the new results presented here are documented for the first time in monographic form.

Autorenportrait

M.Monastyrsky is a professor of mathematics and theoretical physics at the Institute of Theoretical and Experimental Physics,Moscow,Russia, graduated the mathematical department of Moscow state university(1967), author of numerous papers in diferent fields of mathematics and theoretical physics including the monograph:Topology in Gauge Fields and Condensed Matter (Plenum,1993 ) and two other books:Riemann,Topology Physics,Birkhauser,Boston,1999 ,2nd ed. and Modern mathematics in the light of Fields medals,AKPeters,1997.I gave invited plenary talks on many conferences and was the visiting professor of many universities and institutes including IAS(Princeton),Harvard,Princeton and Yale Universities (USA),Cambridge and Oxford Universities (Great Britain), IHES and Universite de Paris (France).

Inhalt

1. Introduction.- 2. Topology in Biology: From DNA Mechanics to Enzymology.- 3. Monte Carlo Simulation of DNA Topological Properties.- 4. Dynamics of DNA Supercoiling.- 5. From Tangle Fractions to DNA.- 6. Linear Behavior of the Writhe Versus the Number of Crossings in Rational Knots and Links.- 7. Combinatories and Topology of the ß-Sandwich and ß-Barrel Proteins.- 8. The Structure of Collagen. 9. Euler Charactristic, Dehn-Sommerville Characteristics, and their Applications.- 10. Hopf Fibration and its Applications.- 11. Multivalued Functionals, One-forms and Deformed de Rham Complex.- 12. The Spectral Geometry of Riemann Surfaces.

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